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Combining Medicinal Mushrooms: 5 Strong Matches

| Reading time 6 Minutes

Can you combine medicinal mushrooms? Yes, you can! Functional (medicinal) mushrooms work synergistically. This means they enhance the effects of each other.

The synergistic effects of medicinal mushrooms

combining medicinal mushrooms

Some studies point to the synergistic effects of medicinal mushrooms (1). For instance, in a study on the benefits of Reishi, Shiitake, and Maitake, researchers stumbled upon the synergy between these three mushrooms.

According to them, this was the first study to report such a synergy. Not entirely surprising according to the researchers; in the field of natural products, the concept of synergy is quite “common.” For example, “synergy is reported between plant natural products for the prevention and/or treatment of cancer and malaria” (2).

Safe combinations of mushroom supplements

What has not yet been reported is any adverse effect of combining different medicinal mushrooms. Combining mushroom supplements is thus considered safe as long as you don’t exceed the daily recommended amount (two capsules per day).

When you first start out combining medicinal mushrooms

Never taken medicinal mushrooms before? Then start with a maximum of two varieties. This is to introduce your body to the new substances. In the beginning, in all your enthusiasm, you may not realise which mushroom will benefit you the most.

By starting slowly, you can at least observe and listen to your body. After a few weeks, introduce a new mushroom and observe what benefits you are experiencing now.

Who benefits the most from medicinal mushrooms?

how to combine medicinal mushrooms

Mushroom supplements can benefit all kinds of people.

  • People who want to optimise their health and cognitive performance will benefit greatly from Chaga, Turkey Tail or Lion’s Mane.
  • People who want to reduce stress or sleep better will benefit from Reishi or Chaga.
  • Athletes and sportsmen who want to increase their endurance will benefit greatly from Cordyceps.

There are several mushrooms, each with their own effects, of which we give a brief overview below. Mushroom supplements from MushPeak are suitable for vegetarians and vegans. Our capsules are gluten-free and non-GMO.

Benefits of medicinal mushrooms

Various health benefits are attributed to functional mushrooms: from strengthening the immune system (Chaga) and improving concentration (Lion’s Mane) to reducing stress (Reishi), strengthening digestion (Turkey Tail), and increasing energy (Cordyceps). And many more!

  • Benefits of Reishi: You can use Reishi for stress and/or anxiety, as it can contribute to a calm mind and healthy sleep. Reishi can also contain anti-inflammatory properties.
  • Benefits of Lion’s Mane: Lion’s Mane is known for its cognitive support and for strengthening memory, as well as for improving concentration, mood, digestion, and the immune system.
  • Benefits of Cordyceps: Cordyceps is used to increase energy, improve athletic performances, increase libido, and to shorten one’s recovery time.
  • Benefits of Chaga: Chaga is known for boosting skin and hair health, for its anti-inflammatory properties, and for containing a high amount of antioxidants.
  • Benefits of Turkey Tail: Turkey Tail is used to support gut health, strengthen the immune system, and improve digestion. It contains anti-inflammatory properties and is rich in antioxidants

combinations of medicinal mushroom supplements

  • For more focus and relaxation: Lion’s Mane and Reishi
  • For healthy hair and anti-ageing: Chaga and Cordyceps
  • For better digestion and a stronger immune system: Turkey Tail and Chaga
  • For better performances and a quick recovery: Cordyceps and Lion’s Mane
  • For more peace in your life: Chaga and Reishi

1. For more focus and relaxation: Lion’s Mane and Reishi

Lion’s Mane is praised for its potential neurotrophic properties, meaning it can promote the growth and survival of nerve cells. It contains bioactive compounds, such as hericenones and erinacins, which are associated with neuroprotective effects.

Studies suggest that Lion’s Mane may be able to support cognitive functions and help improve concentration and memory.

In addition, Reishi is known as an adaptogenic mushroom; it can help regulate the stress response system. There is also evidence that Reishi may help reduce anxiety, which may indirectly contribute to a sense of relaxation.

2. For healthy hair and anti-aging: Chaga and Cordyceps

In Mongolia, Chaga is used as a shampoo to promote healthy hair and scalp. Chaga contains antioxidants, such as polyphenols and melanin. Antioxidants help neutralise free radicals, which are involved in ageing processes.

When oxidative stress is reduced, it can help maintain a youthful appearance and skin health. In addition, Cordyceps is known for its potential effects on energy levels and oxygen uptake in the body. Improved blood flow can contribute to healthy (main) skin.

3. For a strong digestion: Turkey Tail and Chaga

If you want to improve your digestion, then Turkey Tail and Chaga are the ultimate combination. Turkey Tail is known as a prebiotic and can help restore and optimise good bacteria in the intestines.

Chaga has also been used for centuries in traditional Chinese medicine for gut problems. Research shows that it can help reduce inflammation in the intestines and prevent stomach ulcers (3).

4. For better performances: Cordyceps and Lion’s Mane

Cordyceps contains substances that can promote oxygen uptake into cells, which can be useful for optimising athletic performances. Research has even shown that the mushroom significantly prolongs the point of fatigue (4).

Both Cordyceps and Lion’s Mane have anti-inflammatory properties. Intense exercise can lead to the development of inflammation in the body. A balanced inflammatory response thanks to Cordyceps and Lion’s Mane can contribute to faster recovery.

5. For more peace in your life: Chaga and Reishi

The combination of Chaga and Reishi is associated with promoting calmness because of the potential calming and adaptogenic properties of both mushrooms. For instance, they can help to better regulate the stress hormone cortisol.

People experience improvements in their sleep quality with regular use of Chaga and Reishi. And a good night’s sleep is essential for restoring the body and promoting a restful feeling.

Choose your favourite combination of medicinal mushrooms

Do you know which combination of medicinal mushrooms you want? Discover our premium organic mushroom supplements. Each delivery of mushroom supplements is thoroughly tested, so you know exactly what you’re getting. Check out the lab results on the product pages!

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Supplements should not be used as a replacement for a diverse diet, a healthy lifestyle, or as a treatment for any medical condition. Keep this product out of the reach of children. If you are ill, pregnant, or in doubt, always consult with your healthcare provider. The information provided on this website is intended for general informational purposes and should not be considered as medical advice. While traditional Chinese medicine has a history spanning thousands of years and has been tested on numerous individuals, MushPeak does not make claims indicating the proven medicinal properties of herbs or mushrooms, in accordance with current EU legislation. Detailed information about mushrooms is available from publicly accessible sources on the Internet. Please feel free to contact us with any questions.


  1. Mallard B., Leach D.N., Wohlmuth H., & Tiralongo J. (2019). Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake. PLoS ONE 14(11): e0224740.
  2. Verma S.P., Salamone E., & Goldin B. (1997). Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. Biochem Biophys Res Commun, 233(3):692–6.
  3. Xin Xin, Jing Qu, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Kebin Gu. (2019). Assessment of the Gastroprotective Effect of the Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Against the Gastric Mucosal Ulceration Induced by Ethanol in Experimental Rats. International Journal of Medicinal Mushrooms, 21(8): 805-816.
  4. Hirsch K. R., Smith-Ryan A. E., Roelofs E. J., Trexler E. T., & Mock M. G. (2017). Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. Journal of dietary supplements, 14(1), 42-53.

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