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Taking Lion’s Mane at Night: Good or Not?

| Leestijd 7 Minuten

Taking Lion’s Mane at night can work really well. Research indicates that Lion’s Mane supplements (H. erinaceus) can effectively enhance sleep quality. But what’s the mechanism behind this, and is it preferable to consume Lion’s Mane in the morning or at night? Let’s dive into it and get the answers you need.

How can Lion’s Mane help you sleep better?

For many people who have struggled with sleep issues in the past, Lion’s Mane supplements are emerging as a game-changer in their sleep routines. We’ve come across numerous testimonials from our customers, seen discussions in online forums, and found support in various scientific studies.

So how exactly do Lion’s Mane supplements work to enhance sleep quality?

There are several potential explanations:

  • Stress reduction: Research suggests that Lion’s Mane may help alleviate stress and anxiety, both of which are significant contributors to sleep disturbances. Addressing chronic stress is crucial for improving sleep, and Lion’s Mane could offer effective support in this regard.
  • Cognitive enhancement: Lion’s Mane is renowned for its potential cognitive benefits, including enhancing cognitive functions and supporting nerve cell health. Given the close relationship between cognitive processes and sleep quality, optimising brain function with Lion’s Mane could lead to better sleep outcomes.
  • Neurotransmitter modulation: Lion’s Mane has been found to influence the levels of neurotransmitters in the brain, such as serotonin and dopamine, which play key roles in regulating the sleep-wake cycle and mood. By promoting a balance in these neurotransmitters, Lion’s Mane may contribute to more restful sleep.
  • Lion’s Mane possesses anti-inflammatory properties. Some research suggests that inflammatory processes within the body may contribute to sleep disturbances. By mitigating inflammation, Lion’s Mane could indirectly enhance sleep quality.

H. erinaceus improved mood disorders of depressive-anxious nature and quality of sleep

In a 2019 study involving overweight or obese individuals, Lion’s Mane (H. erinaceus) demonstrated promising results in reducing symptoms of depression, anxiety, and sleep disorders following eight weeks of oral administration (1).

While these findings are indeed encouraging, it’s important to acknowledge the study’s limitations, such as its small sample size and the absence of a placebo group. To establish definitive conclusions, larger-scale studies employing randomization and including a placebo group are warranted.

H. erinaceus can be beneficial for people suffering from circadian rhythm disorders and [it can] help alleviate sleep problems”

Furthermore, there’s evidence to suggest that H. erinaceus may offer benefits for people grappling with circadian rhythm disorders and sleep-related issues. A pilot study conducted among female students revealed that four weeks of Lion’s Mane extract administration led to improvements in both well-being and sleep quality (2).

The study noted an increase in free-MHPG levels in saliva, which correlated with reductions in anxiety and enhancements in sleep quality. Nevertheless, similar to the aforementioned study, this was a pilot investigation, necessitating further research to validate these findings.

Are there other experiences with Lion’s Mane at night?

lion's mane experiences with sleeping

Every body is different, so not everyone reacts the same to supplements, medicines, or even food. This can be due to several factors, such as personal sensitivity, dosage, timing of intake, and interactions with medications (or drugs, such as marijuana).

Although the majority of people notice positive effects of Lion’s Mane supplements on their sleep quality, some people get an energy boost from it, especially if they take Lion’s Mane just before sleeping. After all, the mushroom is known for its ability to increase focus.

What should you do if you can’t sleep with Lion’s Mane at night?

If you find that taking Lion’s Mane at night disturbs your sleep, you can either take the supplement earlier in the day or adjust the dosage (for example, to one capsule instead of two).

It’s a matter of experimenting with timing and dosage to discover what works best for your sleep needs and body responses.

The best time to take Lion’s Mane

The best time to take your Lion’s Mane supplements if you want to sleep well can vary depending on your own response to the supplement and your personal routines. Generally, it is recommended to take Lion’s Mane in the morning or early afternoon.

The active ingredients in Lion’s Mane, such as the hericenones and erinacines, can have a stimulating effect on the brain and increase alertness. Therefore, it may be better to take Lion’s Mane in the morning.

Combinations with Lion’s Mane to sleep better

A woman wondering if she can take Lion's Mane before bed

To optimize the effects of Lion’s Mane before bedtime, consider combining the supplement with other medicinal mushroom supplements, as they tend to work synergistically, reinforcing each other’s effects. Just make sure you stick to the recommended daily intake of maximum two capsules per day.

Among the best supplements to pair with Lion’s Mane for better sleep are Reishi, Chaga, and Turkey Tail, each offering unique properties conducive to promoting sleep and overall well-being.

Lion’s Mane with Reishi

Reishi is renowned for its calming and relaxing effects on the body, thanks to its bioactive compounds that alleviate stress, soothe nerves, and enhance sleep quality (3). By blending Reishi with Lion’s Mane, you can capitalise on their synergistic relationship, fostering better sleep and facilitating relaxation at the end of the day.

Lion’s Mane with Chaga

Rich in antioxidants and boasting anti-inflammatory properties, Chaga aids in bolstering the immune system and fostering relaxation, crucial for achieving restorative sleep. Combining Chaga with Lion’s Mane can elevate overall sleep quality, aiding the body in its repair processes during sleep.

Lion’s Mane with Turkey Tail

Turkey Tail is known for its ability to support digestion. Healthy digestion is essential for good sleep and overall health, as it helps absorb nutrients and eliminate waste products. By combining Turkey Tail with Lion’s Mane, you are helping your digestion – and therefore your sleep quality.

Choose premium quality organic Lion’s Mane

Do you want to sleep better with Lion’s Mane? Choose MushPeak’s organic mushroom supplements. Our supplements are (the only ones in Europe) extensively tested by external third-party laboratories, so you know exactly what you are getting. Curious about the results of those tests? You can find them on our product pages!

Discover our mushrooms!

Read more about medicinal mushrooms


Supplements should not be used as a replacement for a diverse diet, a healthy lifestyle, or as a treatment for any medical condition. Keep this product out of the reach of children. If you are ill, pregnant, or in doubt, always consult with your healthcare provider. The information provided on this website is intended for general informational purposes and should not be considered as medical advice. While traditional Chinese medicine has a history spanning thousands of years and has been tested on numerous individuals, MushPeak does not make claims indicating the proven medicinal properties of herbs or mushrooms, in accordance with current EU legislation. Detailed information about mushrooms is available from publicly accessible sources on the Internet. Please feel free to contact us with any questions.


  1. Vigna, L., Morelli, F., Agnelli, G. M., Napolitano, F., Ratto, D., Occhinegro, A., Di Iorio, C., Savino, E., Girometta, C., Brandalise, F., & Rossi, P. (2019). Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Evidence-based complementary and alternative medicine : eCAM, 2019, 7861297.
  2. Hisayoshi Okamura, Nobuko Anno, Akira Tsuda, Takahiro Inokuchi, Naohisa Uchimura, & Kazutoyo Inanaga. (2015). The effects of Hericium erinaceus (Amyloban® 3399) on sleep quality and subjective well-being among female undergraduate students: A pilot study. Personalized Medicine Universe, 4: 76-78.
  3. Xiang-Yu Cui, Su-Ying Cui, Juan Zhang, Zi-Jun Wang, Bin Yu, Zhao-Fu Sheng, Xue-Qiong Zhang, & Yong-He Zhang. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. Journal of Ethnopharmacology, 139(3): 796-800.

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